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    “without trying that much” is a bit misleading. The author went through a basic tutorial of profiling, before suggesting code be rewritten to make use of numpy and Cython.

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      Well, the first thing they did was double the speed of the code with this:

      $ brew install pypy
      $ time pypy alignment.py

      It starts to be trying a little more after that.

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        Fair, but if that was the thesis, it should have stopped right there. :)

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        yea, it seems like in this case, “without trying that much” == “not having to actually handwrite Python C API code”