I’m a bit jaded about talks but Mike Acton’s “Data-Oriented Design” from CPPCon in 2014 was probably the last one to markedly reframe my approach to software design:

https://www.youtube.com/watch?v=rX0ItVEVjHc

Pairs well with Graydon Hoare’s review of Computer Architecture: A Quantitative Approach (the Hennessy and Patterson book): https://graydon2.dreamwidth.org/233585.html