The only time I’ve used Jumbo Frames was between the front and back ends of a news server (early 2000s) because there’s a lot of traffic from the storage to the readers and it made a measurable difference. No issues with routing changes etc. because they had their own subnet for this traffic to avoid saturating other people’s links.
(edit: We may also have used them from the transit boxes to the storage but my memory is vague there.)
The only time I’ve used Jumbo Frames was between the front and back ends of a news server (early 2000s) because there’s a lot of traffic from the storage to the readers and it made a measurable difference. No issues with routing changes etc. because they had their own subnet for this traffic to avoid saturating other people’s links.
(edit: We may also have used them from the transit boxes to the storage but my memory is vague there.)